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KMID : 1161520220260060380
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Animal Cells and Systems
2022 Volume.26 No. 6 p.380 ~ p.387
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LRRK2 decreases microglial actin dynamics by filamentous actin depolymerization and Rac1 inhibition
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Kim Beom-Sue
Suh Young-Ho
Joe Eun-Hye
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Abstract
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An active actin dynamic is a crucial feature of brain microglia. Here we report that LRRK2, a primary familial Parkinson’s disease-associated gene, negatively regulates microglia’s actin dynamics. LRRK2 depolymerized filamentous actin (F-actin) by directly binding to it or inhibiting microglia’s Rac-PAK signaling. LRRK2 knockdown resulted in a reduced ruffle and enhanced lamellipodia formation of ADP-activated microglia, altering the microglia’s physiological activity to vigorous migration toward damaged cells. These results suggest that LRRK2 is a negative regulator for the controlled actin dynamics in microglia.
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KEYWORD
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Actin depolymerization, F-actin-binding proteins, Leucine-rich repeat serine-threonine protein kinase-2, Parkinson disease 8, microglia
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